Figure 3

Experimental design for the effect of ONO1714 in OVA sensitized guinea pigs. 24 h after OVA challenge, vehicle or ONO1714 solutions were first administered 0.5 h prior to cough reflex sensitivity to capsaicin in OVA sensitized guinea pigs weighing 500 to 550 g, and again administered 0.5 h prior to ENO measurement and BAL, which was performed 24 h after the cough reflex sensitivity.