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Characteristic
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Subjects with chronic cough (N = 43)
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Healthy subjects (N = 15)
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Age (years)
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55.6 ± 1.9
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52.7 ± 4.1
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Females – number (%)
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32 (74)
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11 (73)
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Ex smokers – number (%)
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20 (47)
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4 (27)
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Atopic patients – number (%)
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14 (33)
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1 (7)
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Duration of cough (years)
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8.5 ± 1.5
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ND
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Most probable cause of cougha,
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Rhinitis 22 (51)
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ND
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- number (%)
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Esophageal reflux 14 (33)
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Asthma 9 (21)
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Leicester questionnaire total score
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13.2 ± 0.5
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ND
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Cough sensitivity to hypertonic saline (coughs/Osmol/kg)
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7.24 ± 1.03
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ND
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Histamine PD15 (mg)b
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1.28 ± 1.20
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ND
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Nitric oxide concentration (ppm)
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16.8 ± 2.0
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ND
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FEV1 (% of predicted)
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93.7 ± 1.8
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ND
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PEF variation in ambulatory monitoring (%)
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7.13 ± 0.68
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ND
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- Continuous data is expressed as means and standard errors. ND = not done; FEV1:= forced expiratory volume in one second; PD15 = provocative dose of histamine to induce a 15% fall in FEV1. PEF = peak expiratory flow.
- aBased on the results of the Cough Clinic diagnostic questionnaire. Two patients had more than one most probable cause.
- bAmong subjects without a 15% fall in FEV1 in response to histamine, an arbitrary value of 3.2 mg was used as PD15. Histamine challenge was missed in one patient due to technical reasons.
